The world of Blade Runner is about to look very different when Blade Runner 2099 arrives on Prime Video, but fans hoping to see the fallout from Denis Villeneuve’s Blade Runner 2049 might be surprised by the direction the new series takes.

Despite taking place 50 years after the 2017 sequel, showrunner Silka Luisa has confirmed that the upcoming sci-fi series won’t directly continue that film’s story. Instead, it’s designed to introduce audiences to a new chapter of the Blade Runner universe without requiring them to watch either of the previous movies.

Speaking with SFX magazine, Luisa explained: “No, [Blade Runner 2049] is not directly connected to the show,” Luisa told SFX magazine, which features the Prime Video limited series on the new cover. “What was an important early mandate was that audiences could come to the show not having seen the films, and this could stand alone.”

Blade Runner 2049 followed Ryan Gosling as K, a Replicant who discovers that Harrison Ford’s Rick Deckard and Sean Young’s Rachael had a daughter named Ana Stelline. The discovery proved that Replicants could reproduce naturally, something that could completely change the relationship between humans and their artificially created counterparts.

You’d think a revelation that important would play a major role in the franchise’s future, but Blade Runner 2099 has its own story to tell.

The new series takes place following a Replicant uprising that has completely reversed the balance of power. Replicants now control society, while humans have been reduced to second-class citizens.

Michelle Yeoh stars as Olwen, a Replicant Blade Runner approaching the end of her life, while Hunter Schafer plays Cora, a human who disguises herself as a Replicant.

Luisa further explained why the creative team decided to separate the series from the previous films: “This could be an introduction to the world of Blade Runner, and it wouldn’t be dependent on you having watched 2049, [or] you having watched the first Blade Runner. In that sense, we had to divorce ourselves from the narrative.”

While the series won’t directly address the events of Blade Runner 2049, that doesn’t necessarily mean those events had no influence on the world we’re about to explore.

Fifty years is plenty of time for society to change, and it’s entirely possible that Ana Stelline’s existence helped inspire the Replicant uprising. That’s an interesting connection to consider, even if the show never explores it.

Fans also shouldn’t expect K, Deckard, or Ana to make appearances. The focus is firmly on the new characters and the world they’ve inherited.

I actually like the idea of exploring a future where Replicants have taken control and humans are the ones struggling to survive. It flips the franchise’s familiar power dynamic and creates some interesting possibilities for the story.

The big question is whether Blade Runner 2099 can capture the atmosphere, mystery, and philosophical themes that made the original films so memorable while creating something that feels fresh.

We’ll find out when Blade Runner 2099 premieres on Prime Video on November 25.